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Evidence: Clinical study
Logical Profile #valeValerian Root
Valeriana officinalis
Mechanism of Action
"Allosteric modulator at GABA-A receptors; inhibits GABA transaminase degradation enzyme, prolonging inhibitory synaptic tone."
Active Compounds
Valerenic acid
Isovaleric acid
Valepotriates
Linarin
Tissue Affinity
Central Nervous System, Peripheral smooth muscle
Medical Indications
Sleep latency prolongation, somatic anxiety, nocturnal muscular cramping
Dosage Logic
400-600mg standardized extract (0.8% valerenic acid) taken 45 minutes before sleep.
Safety Engine
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Drug Interactions
Benzodiazepines, Zolpidem, Alcohol (additive sedative depression)
Contraindications
Severe liver failure (historical theoretical caution)