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Evidence: Clinical study
Logical Profile #turmTurmeric / Curcumin
Curcuma longa
Mechanism of Action
"Downregulates NF-kB nuclear translocation; directly inhibits COX-2 and 5-LOX enzymes; upregulates Nrf2 phase II antioxidant enzymes."
Active Compounds
Curcumin
Diferuloylmethane
Bisdemethoxycurcumin
Turmerones
Tissue Affinity
Gastrointestinal, Hepatic, Musculoskeletal, Vascular endothelium
Medical Indications
Systemic inflammation, osteoarthritis, metabolic syndrome, neuroprotection
Dosage Logic
Standardized extract (95% curcuminoids) co-formulated with piperine or phospholipid phytosomes for 20-fold bioavailability enhancement.
Safety Engine
Check if Turmeric / Curcumin is safe for your current medications and conditions.
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Drug Interactions
Anticoagulants (Warfarin - moderate), Antiplatelets
Contraindications
Bile duct obstruction, Gallstones (high doses)