Back to Library
Evidence: Clinical study
Logical Profile #st-jSt. John's Wort
Hypericum perforatum
Mechanism of Action
"Non-selective monoamine reuptake inhibitor (5-HT, Dopamine, Norepinephrine); potent Pregnane X Receptor (PXR) ligand inducing hepatic CYP3A4."
Active Compounds
Hyperforin
Hypericin
Pseudohypericin
Flavonoids
Tissue Affinity
Central Nervous System, Peripheral Nerves
Medical Indications
Mild to moderate unipolar depression, neuropathic pain, somatoform disorders
Dosage Logic
300mg standardized extract (0.3% hypericin, 3-5% hyperforin) tid with food. Mandatory prescription cross-check.
Safety Engine
Check if St. John's Wort is safe for your current medications and conditions.
NO PROFILE FOUND
Safety checks require an encrypted Health Mirror profile. No profile data is ever stored on our servers.
Create Health MirrorGeneral Cautions
Drug Interactions
Potent inducer: Cyclosporine, Oral contraceptives, Digoxin, Warfarin, SSRIs
Contraindications
Severe bipolar disorder, Concurrent SSRI/SNRI prescription