Ashwagandha

Withania somnifera

Mechanism of Action

"Modulates GABA-A receptor signaling; suppresses nocturnal serum cortisol spikes; stimulates neurogenesis via neurite outgrowth."

Active Compounds

Withaferin A

Withanolide D

Sominone

Sitoindosides

Tissue Affinity

Central Nervous System, Adrenal Cortex, Thyroid, Muscular tissue

Chronic HPA axis fatigue, generalized anxiety, insomnia, athletic recovery

300-600mg standardized root extract (5% withanolides) with evening meal for sleep architecture modulation.

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General Cautions

Sedatives / Barbiturates (additive sedation), Thyroid hormone replacement

Hyperthyroidism, Pregnancy